Pesquisa | SciELO

Abstract This publication is an update of the “Consensus on the therapeutic management of atopic dermatitis - Brazilian Society of Dermatology” published in 2019, considering the novel, targeted-oriented systemic therapies for atopic dermatitis. The initial recommendations of the current consensus for systemic treatment of patients with atopic dermatitis were based on a recent review of scientific published data and a consensus was reached after voting. The Brazilian Society of Dermatology invited 31 experts from all regions of Brazil and 2 international experts on atopic dermatitis who fully contributed to the process. The methods included an e-Delphi study to avoid bias, a literature search and a final consensus meeting. The authors added novel approved drugs in Brazil and the indication for phototherapy and systemic therapy for AD. The therapeutical response to systemic treatment is hereby reported in a suitable form for clinical practice and is also part of this updated manuscript.

https://doi.org/10.1016/j.abd.2023.04.003

TANINOS E FLAVONOIDES DAS FLORES DE EUGENIA UNIFLORA (MYRTACEAE)
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Souza, Patricia Santana Oliveira de

; Santos, Micheline Thais dos

; Monteiro, Rejane Gonçalves

; Espindola, Maria Tamires Alves

; Souza, Helter José Silva de

; Monteiro, Amanda Lins Bispo

; Camara, Celso de Amorim

; Silva, Tania Maria Sarmento

Química Nova

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Set 2022, Volume 45 Nº 9 Páginas 1083 - 1091

Resumo: Pt | Texto: Pt | PDF: Pt

Eugenia uniflora, popularly known as pitanga, is a native species of the Brazilian flora, widely used in folk medicine for the treatment of various diseases and which has several bioactive chemical constituents. The aim of this work was to analyze the chemical composition of flowers visited by bees from Eugenia uniflora by Ultra-Performance Liquid Chromatography coupled with a Diode Array Detector and quadrupole Time of Flight Mass Spectrometry (UPLC-DAD-qTOF-MS/MS). Forty-four compounds were tentatively identified, including quinic acid, seven tannins and thirty-six flavonoids.

https://doi.org/10.21577/0100-4042.20170920

Absence of neutralizing antibodies against the Omicron SARS-CoV-2 variant in convalescent sera from individuals infected with the ancestral SARS-CoV-2 virus or its Gamma variant
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Villas-Boas, Lucy Santos

; Paula, Anderson Vicente de

; Silva Jr., Almir Ribeiro da

; Paiao, Heuder Gustavo Oliveira

; Tozetto-Mendoza, Tania Regina

; Manuli, Erika Regina

; Leal, Fábio Eudes

; Ferraz, Andrea de Barros Coscelli

; Sabino, Ester Cerdeira

; Bierrenbach, Ana Luiza

; Witkin, Steven Sol

; Mendes-Correa, Maria Cassia

Clinics

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2022, Volume 77 elocation 100068

Resumo: En | Texto: En | PDF: En

Abstract Objectives: The aim of the present study was to evaluate if neutralizing antibody responses induced by infection with the SARS-CoV-2 strain that was dominant at the beginning of the pandemic or by the Gamma variant was effective against the Omicron variant. Methods: Convalescent sera from 109 individuals, never exposed to a SARS-CoV-2 vaccine, who had mild or moderate symptoms not requiring hospitalization following either a documented SARS-CoV-2 ancestral strain infection or a Gamma variant infection, were assayed for in vitro neutralizing antibody activity against their original strains and the Omicron variant. Results: Following an infection with the ancestral strain, 56 (93.3%), 45 (77.6%) and 1 (1.7%) serum sample were positive for neutralizing antibodies against the ancestral, Gamma variant, and Omicron variant, respectively. After infection with the Gamma variant, 43 (87.8%) and 2 (4.1%) sera were positive for neutralizing antibodies against the Gamma and Omicron variants, respectively. Conclusions: Neutralizing antibodies generated following mild or moderate infection with the SARS-CoV-2 ancestral strain or the Gamma variant are not protective against the Omicron variant. HIGHLIGHTS Individuals previously infected with SARS-CoV-2 ancestral strain do not develop neutralizing antibodies against the Omicron variant. Omicron variant escapes immune response after SARS CoV-2 previous infection with the SARS CoV-2 Gamma variant. Individuals previously infected with SARS-CoV-2 ancestral strain or with SARS-CoV-2 Gamma variant will likely have little protection if subsequently exposed to the Omicron variant.

https://doi.org/10.1016/j.clinsp.2022.100068

Recommendations for evaluation and diagnosis of extra-glandular manifestations of primary sjogren syndrome: results of an epidemiologic systematic review/ meta-analysis and a consensus guideline from the Brazilian Society of Rheumatology (articular, pulmonary and renal)
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Trevisani, Virginia Fernandes Moça

; Pugliesi, Alisson

; Pasoto, Sandra Gofinet

; Lopes, Maria Lucia Lemos

; Guedes, Lissiane Karine Noronha

; Miyamoto, Samira Tatiyama

; Fernandes, Marilena Leal Mesquita Silvestre

; Fialho, Sonia Cristina de Magalhães Souza

; Pinheiro, Aysa César

; Santos, Laura Caldas dos

; Appenzeller, Simone

; Fidelix, Tania

; Ribeiro, Sandra Lúcia Euzébio

; Brito, Danielle Christinne Soares Egypto de

; Libório-Kimura, Tatiana Nayara

; Santos, Maria Carmen Lopes Ferreira Silva

; Cantali, Diego Ustárroz

; Gennari, Juliana D’Agostino

; Civile, Vinicius Tassoni

; Pinto, Ana Carolina Pereira Nunes

; Rocha-Filho, César Ramos

; Oliveira, Fabiola Reis

; Rocha, Aline Pereira da

; Valim, Valeria

Advances in Rheumatology

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2022, Volume 62 elocation 18

Resumo: En | Texto: En | PDF: En

Abstract Sjogren’s Syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration of the exocrine glands and other organs, associated with sicca syndrome but also with systemic involvement with varying degrees of severity. Despite their importance, these systemic manifestations are not routinely evaluated and there is no homogenous approach to their diagnosis or evaluation. To close this gap, a panel of experts from the Brazilian Society of Rheumatology conducted a systematic review and meta-analysis on the identification of epidemiologic and clinical features of these manifestations and made recommendations based on the findings. Agreement between the experts was achieved using the Delphi method. The first part of this guideline summarizes the most important topics, and 11 recommendations are provided for the articular, pulmonary, and renal care of SS patients.

https://doi.org/10.1186/s42358-022-00248-1

AÇÃO PÚBLICA SOCIOAMBIENTAL EM QUESTÃO: desafios da cogestão de uma Resex Marinha na Amazônia brasileira
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Oliveira, Marcelo do Vale

; Ribeiro, Tânia Guimarães

; Teisserenc, Maria José da Silva Aquino

Caderno CRH

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2022, Volume 35 elocation e022030

Resumo: Pt En Fr | Texto: Pt En Fr | PDF: Pt | PDF: En | PDF: Fr

O objeto em questão é a participação na construção de um Plano de Manejo, dispositivo exigido pela implementação de um instrumento de política pública ambiental como a Resex. A referência territorial envolve a Resex Marinha Caeté-Taperaçu, situada no município de Bragança, Estado do Pará. O objetivo é compreender como se coproduziu o Plano de Manejo, relacionando-o a um contexto de ambientalização e participação para demonstrar as relações entre os atores envolvidos, seus conhecimentos, práticas e interesses em confronto. A partir de uma abordagem sociológica da ação pública, traz-se uma perspectiva das políticas públicas onde o Estado tem sua centralidade contestada e onde a participação de diferentes atores nas discussões e gerenciamento de seu território, se não tem sido evidente, não deixou também de se constituir enquanto horizonte de governança a ser buscado em dinâmicas e mobilizações locais, expressas na capacidade dos atores e de sua atuação em ações coletivas.

The object in question is participation in the construction of a Management Plan, a device required by the implementation of environmental public political instrument such as Resex. The territorial reference involves the Caeté-Taperaçu Marine Resex, located in the municipality of Bragança, state of Pará. The objective is to understand how the Management Plan was co-produced, relating it to a context of environmentalization and participation, to demonstrate the relationships between the actors involved, their knowledge, practices and interests in confrontation. From a sociological approach to public action brings a perspective of public policies, where the state has its centrality challenged and where the participation of different actors in the discussions and management of its territory has not been evident, but also constitute as a horizon of governance to be sought in local dynamics and mobilizations, expressed in the capacity of the actors and their performance in collective actions.

L'objet en question est la participation à la construction d'un plan de gestion, un disposit if requis par la mise en œuvre d'un instrument de politique publique environnementale tel que Resex. La référence territoriale concerne le Résex marin Caeté-Taperaçu, situé dans la municipalité de Bragança, dans l’État de Pará. Dont l'object if est de comprendre comment le plan de gestion a été coproduit, en le reliant à un contexte d'environnement alisation et de participation, afin de démontrer les relations entre les acteurs impliqués, leurs connaissances, leurs pratiques et leurs intérêts en confrontation. L'approche sociologique de l'action publique donne une perspective des politiques publiques, où la centralité de l’État est contestée et où la participation de différents acteurs aux discussions et à la gestion de son territoire n'a pas été évidente, mais où constituer comme un horizon de gouvernance à rechercher dans les dynamiques et les mobilisations locales, se traduisant par la capacité des acteurs et leur performance dans les actions collectives.

https://doi.org/10.9771/ccrh.v35i0.34542

Recommendations for evaluation and diagnosis of extra-glandular manifestations of primary Sjögren syndrome: results of an epidemiologic systematic review/ meta-analysis and a consensus guideline from the Brazilian society of rheumatology (hepatic, gastrointestinal and pancreatic)
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Trevisani, Virginia Fernandes Moça

; Pinheiro, Aysa César

; Fialho, Sonia Cristina de Magalhães Souza

; Fernandes, Marilena Leal Mesquita Silvestre

; Pugliesi, Alisson

; Pasoto, Sandra Gofinet

; Lopes, Maria Lucia Lemos

; Guedes, Lissiane Karine Noronha

; Miyamoto, Samira Tatiyama

; Santos, Laura Caldas dos

; Appenzeller, Simone

; Fidelix, Tania

; Ribeiro, Sandra Lúcia Euzébio

; Brito, Danielle Christinne Soares Egypto de

; Libório-Kimura, Tatiana Nayara

; Santos, Maria Carmen Lopes Ferreira Silva

; Cantali, Diego Ustárroz

; Gennari, Juliana D.’Agostino

; Capobianco, Karina Gatz

; Civile, Vinicius Tassoni

; Pinto, Ana Carolina Pereira Nunes

; Rocha, Aline Pereira da

; Rocha Filho, César Ramos

; Oliveira, Fabiola Reis

; Valim, Valeria

Advances in Rheumatology

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2022, Volume 62 elocation 35

Resumo: En | Texto: En | PDF: En

Abstract Sjogren's syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration of the exocrine glands and other organs, associated with sicca syndrome but also with systemic involvement with varying degrees of severity. Despite their importance, some systemic manifestations, mainly liver, gastrointestinal, and pancreatic are not routinely evaluated. To address these manifestations, the Sjögren's Syndrome Committee of the Brazilian Society of Rheumatology conducted a broad systematic review of the literature on studies investigating prevalence and diagnosis of these symptoms in Sjogren´s patients and made recommendations based on the findings. Agreement between the experts was achieved using the Delphi method. This is the second part of this guideline, providing 6 recommendations for liver, gastrointestinal, and pancreatic care of SS patients.

https://doi.org/10.1186/s42358-022-00267-y

DA SOLIDÃO À COOPERAÇÃO: ESTRATÉGIAS DE ENFRENTAMENTO DE TRABALHADORES DE ENFERMAGEM DE TERAPIA INTENSIVA
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Oliveira, Estefânia da Silva

; Centenaro, Alexa Pupiara Flores Coelho

; Garcia, Cledir Tânia França

; Flores, Cíntia Maria Lovato

; Franco, Gianfábio Pimentel

; Glowacki, Júlia

Cogitare Enfermagem

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2022, Volume 27 elocation e82791

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo: conhecer as estratégias de enfrentamento desenvolvidas pelos trabalhadores de enfermagem de Unidades de Terapia Intensiva para a manutenção da saúde mental. Método: estudo qualitativo descritivo, com trabalhadores de enfermagem de três Centros de Cuidados Intensivos de um estado do sul do Brasil. Dados coletados entre junho de 2019 e julho de 2021 por meio de entrevista semiestruturadas e submetidos à análise temática de conteúdo. Resultados: desvelaram-se estratégias de enfrentamento individuais baseadas em situações geradoras de sofrimento. Evidenciou-se a solidão do trabalho, resultado dos descompassos entre os espaços terapêuticos oferecidos pela instituição e as demandas dos trabalhadores. Por fim, identificou-se a possibilidade de ressignificação da solidão em cooperação por meio das estratégias coletivas como caminho para enfrentamento do sofrimento no trabalho e como fator protetor de maior eficácia. Conclusão: podem-se promover ações coletivas de enfrentamento e atividades que fortaleçam a união e cooperação das equipes de enfermagem em terapia intensiva.

ABSTRACT Objective: to know the coping strategies developed by intensive care unit nurse practioners to maintain mental health. Method: qualitative descriptive study, with nursing workers from three Intensive Care Centers in a southern state of Brazil. Data collected between June 2019 and July 2021 through semi-structured interviews and submitted to thematic content analysis. Results: individual coping strategies based on situations that generate suffering were unveiled. The loneliness of work was evidenced because of the mismatches between the therapeutic spaces offered by the institution and the demands of the workers. Finally, the possibility of re-signifying loneliness in cooperation through collective strategies was identified as a path to face suffering at work and as a protective factor of greater effectiveness. Conclusion: collective coping actions and activities that strengthen the union and cooperation of intensive care nursing teams can be promoted.

RESUMEN Objetivo: conocer las estrategias de afrontamiento desarrolladas por los trabajadores de enfermería de las Unidades de Cuidados Intensivos para el mantenimiento de la salud mental. Método: estudio cualitativo descriptivo, con trabajadores de enfermería de tres Centros de Cuidados Intensivos de un estado del sur de Brasil. Datos recogidos entre junio de 2019 y julio de 2021 mediante entrevistas semiestructuradas y sometidos a análisis de contenido temático. Resultados: se desarrollaron estrategias de afrontamiento individuales basadas en situaciones de riesgo de soborno. Se evidenció la solidez del trabajo, resultado de los desajustes entre los espacios terapéuticos ofrecidos por la institución y las demandas de los trabajadores. Por último, se identificó la posibilidad de resignificar la solidaridad en la cooperación mediante las estrategias colectivas como camino para enfrentar el sufrimiento en el trabajo y como factor protector de mayor eficacia. Conclusión: se pueden promover acciones colectivas de afrontamiento y actividades que fortalezcan la unión y cooperación de los equipos de enfermería en cuidados intensivos.

https://doi.org/10.5380/ce.v27i0.82791

Elderly people’s experiences in emergencies through access to other levels of health care
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Oliveira, Ana Luíza Barreto de

; Menezes, Tânia Maria de Oliva

; Freitas, Adriana Valéria da Silva

; Reis, Luana Araújo dos

; Sales, Marta Gabriele Santos

; Santos, Alana Libânia de Souza

; Santos, Lucivalda Barbosa

Revista Brasileira de Enfermagem

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2021, Volume 74 Supl. 2 elocation e20200423

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo: compreender o vivido pelo idoso nas emergências pelo acesso para outros níveis de atenção à saúde. Métodos: estudo fenomenológico à luz de Heidegger, realizado com 19 idosos internados em Unidade de Pronto Atendimento do município de Salvador, entre os meses de abril e outubro de 2019. Resultados: primado ôntico: Disposição do vivido da pessoa idosa à espera pela regulação; Angústia e medo constitutivos na disposição de ser idoso à espera pela regulação em Unidade de Pronto Atendimento; Ser idoso impróprio suprimido na espera pela regulação; Ser idoso próprio desvelado na modalidade existenciária de ser para a morte. Primado ontológico: Cura como ser da presença da pessoa idosa à espera pela regulação. Considerações finais: o ser idoso se angustia e tem medo, sentimentos que permitem o questionamento do próprio ser, que deseja a cura e busca caminhos que permite uma participação ativa e própria no cuidado.

ABSTRACT Objective: to understand elderly people’s experiences in emergencies through access to other levels of health care. Methods: a phenomenological study in the light of Heidegger, conducted with 19 elderly patients admitted to an Emergency Care Unit of the city of Salvador, between April and October 2019. Results: ontic primacy: Disposition of the experience of elderly people waiting for regulation; Constitutional anguish and fear in the willingness to be an elderly person waiting for regulation in an Emergency Care Unit; Inappropriate elderly being suppressed while waiting for regulation; Being an elderly person unveiled in the existential modality of being for death. Ontological primacy: Heal how to be the presence of elderly people waiting for regulation. Final considerations: elderly people being anguished and afraid, feelings that allow the questioning of their own being, who want a healing and seeks ways that allows an active and proper participation in care.

RESUMEN Objetivo: comprender lo que viven los ancianos en situaciones de emergencia a través del acceso a otros niveles de atención de la salud. Métodos: estudio fenomenológico a la luz de Heidegger, realizado con 19 pacientes ancianos ingresados en la Unidad de Urgencias de la ciudad de Salvador, entre los meses de abril y octubre de 2019. Resultados: primacía óntica: disposición de la experiencia del anciano en espera de regulación; Angustia constitucional y miedo ante la voluntad de ser un anciano en espera de regulación en una unidad de emergencia; Ancianos inapropiados reprimidos mientras esperan la regulación; Ser un anciano desvelado en la modalidad existencial del ser para la muerte. Primacía ontológica: Cura cómo ser la presencia del anciano esperando la regulación. Consideraciones finales: el anciano está angustiado y asustado, sentimientos que permiten el cuestionamiento de su propio ser, que quiere una cura y busca caminos que le permitan una participación activa y adecuada en el cuidado.

https://doi.org/10.1590/0034-7167-2020-0423 402 downloads

2021 recommendations of the Brazilian Society of Rheumatology for the gynecological and obstetric care of patients with Sjogren’s syndrome
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Oliveira, Fabiola Reis

; Valim, Valeria

; Pasoto, Sandra Gofinet

; Fernandes, Marilena Leal Mesquita Silvestre

; Lopes, Maria Lucia Lemos

; Souza Fialho, Sonia Cristina de Magalhães

; Pinheiro, Aysa César

; Santos, Laura Caldas dos

; Appenzeller, Simone

; Fidelix, Tania

; Ribeiro, Sandra Lucia Euzébio

; Brito, Danielle Christinne Soares Egypto de

; Libório, Tatiana

; Santos, Maria Carmen Lopes Ferreira Silva

; Tanure, Leandro

; Gennari, Juliana DAgostino

; Civile, Vinicius Tassoni

; Pinto, Ana Carolina Pereira Nunes

; Rocha Filho, César Ramos

; Miyamoto, Samira Tatiyama

; Guedes, Lissiane Karine Noronha

; Pugliesi, Alisson

; Trevisani, Virginia Fernandes Moça

Advances in Rheumatology

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2021, Volume 61 elocation 54

Resumo: En | Texto: En | PDF: En

Abstract Sjogren’s syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration of the exocrine glands and other organs. Women with SS often experience gynecological symptoms due to the disease and need extra care regarding their sexual activity, reproductive health and during pregnancy, conditions that are not properly conducted in the clinical practice. To cover this gap, a panel of experts from the Brazilian Society of Rheumatology conducted a systematic review and meta-analysis on the identification of symptoms, diagnosis, monitoring, prognosis, and treatment of these manifestations. A Focus Group meeting was held and included experts in the field and methodologists, based on a previously developed script, with themes related to the objective of the study. The most important topics were summarized and 11 recommendations were provided.

https://doi.org/10.1186/s42358-021-00208-1 54 downloads

10.

Differences in children and adolescents with SARS-CoV-2 infection: a cohort study in a Brazilian tertiary referral hospital
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Marques, Heloisa Helena de Sousa

; Pereira, Maria Fernanda Badue

; Santos, Angélica Carreira dos

; Fink, Thais Toledo

; Paula, Camila Sanson Yoshino de

; Litvinov, Nadia

; Schvartsman, Claudio

; Delgado, Artur Figueiredo

; Gibelli, Maria Augusta Bento Cicaroni

; Carvalho, Werther Brunow de

; Odone Filho, Vicente

; Tannuri, Uenis

; Carneiro-Sampaio, Magda

; Grisi, Sandra

; Duarte, Alberto José da Silva

; Antonangelo, Leila

; Francisco, Rossana Pucineli Vieira

; Okay, Thelma Suely

; Batisttella, Linamara Rizzo

; Carvalho, Carlos Roberto Ribeiro de

; Brentani, Alexandra Valéria Maria

; Silva, Clovis Artur

; Eisencraft, Adriana Pasmanik

; Rossi Junior, Alfio

; Fante, Alice Lima

; Cora, Aline Pivetta

; Reis, Amelia Gorete A. de Costa

; Ferrer, Ana Paula Scoleze

; Andrade, Anarella Penha Meirelles de

; Watanabe, Andreia

; Gonçalves, Angelina Maria Freire

; Waetge, Aurora Rosaria Pagliara

; Silva, Camila Altenfelder

; Ceneviva, Carina

; Lazari, Carolina dos Santos

; Abellan, Deipara Monteiro

; Santos, Emilly Henrique dos

; Sabino, Ester Cerdeira

; Bianchini, Fabíola Roberta Marim

; Alcantara, Flávio Ferraz de Paes

; Ramos, Gabriel Frizzo

; Leal, Gabriela Nunes

; Rodriguez, Isadora Souza

; Pinho, João Renato Rebello

; Carneiro, Jorge David Avaizoglou

; Paz, Jose Albino

; Ferreira, Juliana Carvalho

; Ferranti, Juliana Ferreira

; Ferreira, Juliana de Oliveira Achili

; Framil, Juliana Valéria de Souza

; Silva, Katia Regina da

; Kanunfre, Kelly Aparecida

; Bastos, Karina Lucio de Medeiros

; Galleti, Karine Vusberg

; Cristofani, Lilian Maria

; Suzuki, Lisa

; Campos, Lucia Maria Arruda

; Perondi, Maria Beatriz de Moliterno

; Diniz, Maria de Fatima Rodrigues

; Fonseca, Maria Fernanda Mota

; Cordon, Mariana Nutti de Almeida

; Pissolato, Mariana

; Peres, Marina Silva

; Garanito, Marlene Pereira

; Imamura, Marta

; Dorna, Mayra de Barros

; Luglio, Michele

; Rocha, Mussya Cisotto

; Aikawa, Nadia Emi

; Degaspare, Natalia Viu

; Sakita, Neusa Keico

; Udsen, Nicole Lee

; Scudeller, Paula Gobi

; Gaiolla, Paula Vieira de Vincenzi

; Severini, Rafael da Silva Giannasi

; Rodrigues, Regina Maria

; Toma, Ricardo Katsuya

; Paula, Ricardo Iunis Citrangulo de

; Palmeira, Patricia

; Forsait, Silvana

; Farhat, Sylvia Costa Lima

; Sakano, Tânia Miyuki Shimoda

; Koch, Vera Hermina Kalika

; Cobello Junior, Vilson

Clinics

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2021, Volume 76 elocation e3488

Resumo: En | Texto: En | PDF: En

OBJECTIVES: To compare demographic/clinical/laboratory/treatments and outcomes among children and adolescents with laboratory-confirmed coronavirus disease 2019 (COVID-19). METHODS: This was a cross-sectional study that included patients diagnosed with pediatric COVID-19 (aged <18 years) between April 11, 2020 and April 22, 2021. During this period, 102/5,951 (1.7%) of all admissions occurred in neonates, children, and adolescents. Furthermore, 3,962 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection samples were processed in patients aged <18 years, and laboratory-confirmed COVID-19 occurred in 155 (4%) inpatients and outpatients. Six/155 pediatric patients were excluded from the study. Therefore, the final group included 149 children and adolescents (n=97 inpatients and 52 outpatients) with positive SARS-CoV-2 results. RESULTS: The frequencies of sore throat, anosmia, dysgeusia, headache, myalgia, nausea, lymphopenia, pre-existing chronic conditions, immunosuppressive conditions, and autoimmune diseases were significantly reduced in children and adolescents (p<0.05). Likewise, the frequencies of enoxaparin use (p=0.037), current immunosuppressant use (p=0.008), vasoactive agents (p=0.045), arterial hypotension (p<0.001), and shock (p=0.024) were significantly lower in children than in adolescents. Logistic regression analysis showed that adolescents with laboratory-confirmed COVID-19 had increased odds ratios (ORs) for sore throat (OR 13.054; 95% confidence interval [CI] 2.750-61.977; p=0.001), nausea (OR 8.875; 95% CI 1.660-47.446; p=0.011), and lymphopenia (OR 3.575; 95% CI 1.355-9.430; p=0.010), but also had less hospitalizations (OR 0.355; 95% CI 0.138-0.916; p=0.032). The additional logistic regression analysis on patients with preexisting chronic conditions (n=108) showed that death as an outcome was significantly associated with pediatric severe acute respiratory syndrome (SARS) (OR 22.300; 95% CI 2.341-212.421; p=0.007) and multisystem inflammatory syndrome in children (MIS-C) (OR 11.261; 95% CI 1.189-106. 581; p=0.035). CONCLUSIONS: Half of the laboratory-confirmed COVID-19 cases occurred in adolescents. Individuals belonging to this age group had an acute systemic involvement of SARS-CoV-2 infection. Pediatric SARS and MIS-C were the most important factors associated with the mortality rate in pediatric chronic conditions with COVID-19.

https://doi.org/10.6061/clinics/2021/e3488

11.

SARS-CoV-2 recombinant proteins stimulate distinct cellular and humoral immune response profiles in samples from COVID-19 convalescent patients
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Silva, Laís Teodoro da

; Ortega, Marina Mazzilli

; Tiyo, Bruna Tiaki

; Viana, Isabelle Freire Tabosa

; Lima, Tayná Evily de

; Tozetto-Mendoza, Tania Regina

; Oliveira, Luanda Mara da Silva

; Teixeira, Franciane Mouradian Emidio

; Lins, Roberto Dias

; Almeida, Alexandre de

; Mendes-Correa, Maria Cassia

; Duarte, Alberto Jose da Silva

; Oshiro, Telma Miyuki

Clinics

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2021, Volume 76 elocation e3548

Resumo: En | Texto: En | PDF: En

OBJECTIVES: In this preliminary study we investigated cellular and humoral immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigens in blood samples from 14 recovered coronavirus disease 2019 (COVID-19) patients and compared them to those in samples from 12 uninfected/unvaccinated volunteers. METHODS: Cellular immunity was assessed by intracellular detection of IFN-γ in CD3+ T lymphocytes after stimulation with SARS-CoV-2 spike (S1), nucleocapsid (NC), or receptor-binding domain (RBD) recombinant proteins or overlapping peptide pools covering the sequence of SARS-CoV-2 spike, membrane and nucleocapsid regions. The humoral response was examined by ELISAs and/or chemiluminescence assays for the presence of serum IgG antibodies directed to SARS-CoV-2 proteins. RESULTS: We observed differences between humoral and cellular immune profiles in response to stimulation with the same proteins. Assays of IgG antibodies directed to SARS-CoV-2 NC, RBD and S1/S2 recombinant proteins were able to differentiate convalescent from uninfected/unvaccinated groups. Cellular immune responses to SARS-CoV-2 protein stimuli did not exhibit a specific response, as T cells from both individuals with no history of contact with SARS-CoV-2 and from recovered donors were able to produce IFN-γ. CONCLUSIONS: Determination of the cellular immune response to stimulation with a pool of SARS-CoV-2 peptides but not with SARS-CoV-2 proteins is able to distinguish convalescent individuals from unexposed individuals. Regarding the humoral immune response, the screening for serum IgG antibodies directed to SARS-CoV-2 proteins has been shown to be specific for the response of recovered individuals.

https://doi.org/10.6061/clinics/2021/e3548

12.

ADHERENCE TO THE MEDITERRANEAN DIET IN ELEMENTARY SCHOOL CHILDREN (1ST CYCLE)
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Marques, Goreti Filipa Santos

; Pinto, Sara Maria Oliveira

; Reis, Ana Catarina Rodrigues da Silva

; Martins, Tânia Daniela Barbosa

; Conceição, Ana Paula da

; Pinheiro, Ana Rita Vieira

Revista Paulista de Pediatria

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2021, Volume 39 elocation e2019259

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Caracterizar a adesão à dieta mediterrânica de alunos de escolas primárias do Porto e Maia e analisar a sua associação com a higiene do sono, a atividade física, o risco cardiometabólico e o desempenho escolar. Métodos: Estudo transversal com 891 alunos portugueses: 455 meninos (51%) e 436 meninas (49%), entre 9 e 11 anos (média [M]= 9,2; desvio padrão [DP]= 0,4), peso médio 35,9 kg (DP= 8,1), estatura média 1,4 cm (DP= 0,1), índice de massa corporal médio (IMC padronizado por escore Z para a faixa etária pediátrica) 0,76 (DP= 1,2), 59,5% de pessoas com peso adequado e 15,9% de obesos. Os alunos completaram o Índice de Qualidade de Adesão à Dieta Mediterrânica em Crianças e Adolescentes (Mediterranean Diet Quality Index in Children and Adolescents [KIDMED]) e uma entrevista sociodemográfica e dados antropométricos, após obtenção do consentimento informado dos pais. Resultados: Os resultados sugerem altos níveis de adesão ao padrão alimentar mediterrânico (77,6%), tanto nos meninos como nas meninas. Recorrendo ao coeficiente de correlação de Pearson, encontramos associação positiva entre o escore Z e o risco cardiometabólico, associação negativa entre o escore Z e a média de horas de sono em um dia típico nos meninos e nas meninas, associação positiva entre o escore Z e a idade de início de uma atividade física extracurricular e associação negativa entre o KIDMED e a idade de início da atividade física. Conclusões: Este estudo contribuiu para o conhecimento da adesão ao padrão alimentar mediterrânico de alunos do 1º ciclo de escolaridade do Porto e da Maia e correlações com variáveis associadas a um estilo de vida mais saudável (adesão à dieta mediterrânica, horas de sono e atividade física). Estudos futuros deverão focar a sua atenção em outros países e com amostras mais heterogêneas.

ABSTRACT Objective: To characterize the adherence to the Mediterranean diet (MD) in students from elementary schools in Porto and Maia and analyze its association with sleep hygiene, physical activity, cardiometabolic risk, and school performance. Methods: This is a cross-sectional study with 891 Portuguese students: 455 boys (51%) and 436 girls (49%), aged between 9 and 11 years old (mean [M]=9.2, standard deviation [SD]=0.4), with an average weight of 35.9 kg (SD=8.1), average height of 1.4 m (SD=0.1), average body mass index (standardized BMI Z score for the pediatric age group) of 0.76 (SD=1.21); 59.5% of them had normal weight and 15.9% were obese. The students filled a questionnaire on the adherence to the Mediterranean Diet (Mediterranean Diet Quality Index in Children and Adolescents [KIDMED]), participated in a socio-demographic interview, and had their anthropometric data collected after their parents signed the informed consent form. Results: The results suggest high levels of adherence to the MD (77.6%) both in males and females. Using Pearson’s correlation coefficient, we found that the Z score was positively associated to cardiometabolic risk and the starting age of an extracurricular physical activity, and negatively associated to the average hours of sleep on a typical day both in males and females. We also identified a negative relation between KIDMED and the starting age of physical activity. Conclusions: This study has contributed to the knowledge of adherence to the MD among Portuguese elementary students and correlations with variables associated to a healthier lifestyle (MD, hours of sleep, and physical activity). Future studies should focus their attention on other countries and more heterogeneous samples.

https://doi.org/10.1590/1984-0462/2021/39/2019259 1917 downloads

13.

Influência das práticas de educação em saúde nas responsabilidades de enfermeiros, agentes de saúde e cuidadores familiares no cuidado a idosos dependentes
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Ferraz dos Anjos, Karla

; Silva de Oliveira Boery, Rita Narriman

; de Oliva Menezes, Tânia Maria

; Alves Vilela, Alba Benemérita

; de Oliveira Santa Rosa, Darci

Revista Cubana de Enfermería

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Dez 2020, Volume 36 Nº 4 elocation e3476

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Introdução: As práticas educativas em saúde tem potencial transformador no cotidiano das pessoas e os profissionais de saúde têm responsabilidades para com a sua concretização. Objetivo: Avaliar a influência de práticas educativas em saúde nas responsabilidades de enfermeiros, agentes comunitários de saúde e cuidadores familiares pelo cuidado do idoso dependente. Métodos: Estudo qualitativo, descritivo e exploratório, realizado em município da Bahia, com dois enfermeiros, oito agentes comunitários de saúde e seis cuidadores familiares de idosos que participaram de práticas educativas em saúde. Utilizou-se para coleta de dados questionário e roteiro de entrevista semiestruturados e análise a partir da Técnica da Configuração Triádica, Humanista-existencial-personalista. Resultados: As práticas educativas possibilitaram mudanças nas responsabilidades dos profissionais como na abordagem dos idosos, na atenção à saúde, na cobrança dos familiares pelo cuidado e na compreensão das dificuldades dos idosos e de suas famílias. Entre os cuidadores, houve modificações no cuidado, na aceitabilidade da condição de dependência do idoso e na busca de assistência à saúde. Conclusão: As práticas educativas favoreceram entre os participantes a aquisição de conhecimentos, empoderamento e influenciaram positivamente nas responsabilidades pelo cuidado do idoso, evidenciadas na realização de visitas domiciliares dos profissionais e na cobrança de cuidadores por atendimento domiciliar.

ABSTRACT Introduction: health education practices have the potential to transformer into people's daily lives and health professionals have responsibilities for their implementation. Objective: to evaluate the influence of health education practices on the responsibilities of nurses, community health agents and family caregivers for the care of the dependent elderly. Methods: qualitative, descriptive and exploratory study, conducted in a municipality in the interior of Bahia, with two nurses, eight community health agents and six family caregivers of elderly who participated in health education practices. It was used for data collection questionnaire and semi-structured interview script, production of data in 2016, analysis from Triadic Configuration Technique, humanist-existential-personalist. Results: educational practices allowed changes in responsibilities of professionals such approaching the elderly, health care, recovery of family members for care and understanding of difficulties of elderly and their families. Among the caregivers, there were changes in care, acceptability of dependency condition of elderly and in the search for health care. Conclusion: educational practices favored among the participants acquisition of knowledge, empowerment and positively influenced the responsibilities for the care of elderly, evidenced in home visits of professionals and collection caregivers for home care.

RESUMEN Introducción: Las prácticas de educación en salud tienen un potencial transformador en la vida cotidiana de las personas, y los profesionales de salud tienen la responsabilidad de su implementación. Objetivo: Evaluar la influencia de las prácticas de educación sanitaria en las responsabilidades de enfermeras, agentes de salud comunitarios y cuidadores familiares para el cuidado de los ancianos dependientes. Métodos: Estudio cualitativo, descriptivo y exploratorio, realizado en municipio del interior de Bahía, con 2 enfermeras, 8 agentes comunitarios de salud y 6 cuidadores familiares de ancianos que participaron en prácticas de educación sanitaria. Se utilizó para el cuestionario de recopilación de datos y el guion de entrevista semiestructurada, con producción de datos en 2016, con análisis de la Técnica de Configuración Triádica, humanista-existencial-personalista. Resultados: Las prácticas educativas permitieron cambios en las responsabilidades de los profesionales, como acercarse a los ancianos, la atención médica, la recuperación de los miembros de la familia para el cuidado y la comprensión de las dificultades de los ancianos y sus familias. Entre los cuidadores, hubo cambios en la atención, la aceptabilidad de la condición de dependencia de los ancianos y la búsqueda de atención médica. Conclusión: Las prácticas educativas favorecieron la adquisición de conocimiento entre los participantes, el empoderamiento e influyeron positivamente en las responsabilidades para el cuidado de los ancianos, evidenciado en las visitas domiciliarias de profesionales y la colección de cuidadores para el cuidado domiciliario.

14.

Factors associated with spontaneous abortion: a systematic review
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Oliveira, Maria Tânia Silva

; Oliveira, Caline Novais Teixeira

; Marques, Lucas Miranda

; Souza, Cláudio Lima

; Oliveira, Márcio Vasconcelos

Revista Brasileira de Saúde Materno Infantil

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Jun 2020, Volume 20 Nº 2 Páginas 361 - 372

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Objetivos: compilar estudos produzidos acerca dos fatores de risco genéticos e não genéticos associados a ocorrência de aborto espontâneo. Métodos: trata-se de um artigo de revisão sistemática, com estudos publicados entre janeiro de 2008 a novembro de 2018 nas bases de dados SciELO, PubMed, Lilacs e BVS. Resultados: um total de 567 artigos foram encontrados. Após aplicação dos critérios de elegibilidade definidos, 44 artigos compuseram a presente revisão com a maioria publicada na Ásia, entre os anos de 2008 a 2011, e 10 artigos publicados no Brasil. Causas não genéticas, como fatores sociodemográficos e estado de saúde, estiveram entre as condições mais associadas ao abortamento espontâneo. No continente asiático houve predominância na correlação do aborto espontâneo com fatores relacionados ao estilo de vida como obesidade, tabagismo e atividades laborais; já nas Américas destacam-se causas relacionadas aos fatores sociodemográficos, como baixa renda e baixa escolaridade. Conclusões: os fatores de risco diferem em relação a região de ocorrência, sendo importante a realização de estudos detalhados para que sejam capazes de subsidiar a implantação de políticas públicas e, assim, minorar a ocorrência de abortos.

Abstract Objectives: to compile studies produced regardinggenetic and non-genetic risks factors associated with occurrence of spontaneous abortion. Methods: it talks about a systematic review article, with studies between January of 2008 to November of 2018 according to SciELO, PubMed, Lilacs and BVS. Results: in total, 567 articles were found. After applying the definedeligibility criteria, 44 articles made part of the review, being the majority published on Asia between 2008 and 2011, and 10 articles published on Brazil. Not genetic causes like sociodemographic factors and healthy state were among the most associated conditions of spontaneous abortion. Asiatic continent had predominance about the correlation of spontaneous abortion with factors related to life style like obesity, smoking and labor activities, on the other hand, in the Americas, causes related to sociodemographics factors like low pay and low studies are high-lighted. Conclusions: the risk factors change about the occurrence region, being important to make local studies capable of subsidize the implantation of public politics and to reduce abortions.

https://doi.org/10.1590/1806-93042020000200003 6192 downloads

15.

Leprosy in the elderly population of an endemic state in the Brazilian Northeast (2001-2017): epidemiological scenario,
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Souza, Carlos Dornels Freire de

; Fernandes, Tânia Rita Moreno de Oliveira

; Matos, Thais Silva

; Tavares, Clódis Maria

Anais Brasileiros de Dermatologia

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Fev 2020, Volume 95 Nº 1 Páginas 91 - 94

Resumo: En | Texto: En | PDF: En

Abstract This ecological study aims to analyze both the tendency and the characteristics of leprosy in the elderly population in the state of Bahia, 2001-2017. The tendency was analyzed through joinpoint regression. Epidemiological variables were also included in the study. The average detection rate was 38.73/100,000, with prevalence of men (45.19/100,000). A downward trend occurred in both genders, from 2004, with a greater magnitude in women (annual percent change [APC] = −3.4%). Men presented higher proportions of the multibacillary forms and physical disabilities. The epidemiological scenario indicates the need of implementation of actions that stimulate early diagnosis and treatment of the elderly population.

https://doi.org/10.1016/j.abd.2019.01.011 294 downloads

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